Alzheimer's Reading Room

Despite being the subject of decades of research, we have made little progress in preventing or curing Alzheimer’s disease. We’ve developed a wide range of treatments for Alzheimer’s including cholinesterase inhibitors such as Galantamine, glutimate regulators, and a variety of nootropic drugs. A drug called Crenezumab has been in the news lately. Most media outlets are hearlding it as a possible “Alzheimer’s vaccine”, while some are deceptively implying it will actually cure Alzheimers...Read Full Story

Caregivers, and healthcare professionals, here is some great informationHere is a great dementia resource for caregivers and healthcare professinals,Your residents will love the Amazon Kindle FireHere is information on being the best caregiver you can beHere is a way for nurses administrators, social workers and other health care  professionals to get an easyceu or twoFollow alzheimersideas on twitterThe Dementia Caregiver's Little Book of Hope [Kindle Edition]Technology ReviewA recently...Read Full Story

I woke up around 1 AM and distinctly heard a change in Dotty's breathing.By Bob DeMarco Alzheimer's Reading Room On Death and Dying Dotty is still with us. Things have taken a turn for the worse. She is comfortable right now, but is more disoriented than ever before. Oddly, I was able to sleep more last night than any other night, but right now I am feeling tired. A different kind of tired. Not physical, more mental. I definitely used a lot of cognitive energy last night. Here is the...Read Full Story

As I was rubbing her feet, Dotty's eyes popped open and she gave me that sweet little Dotty smile.By Bob DeMarco Alzheimer's Reading Room Dotty didn't say anything most of the day yesterday even though I talked with her quite a bit. She was saying a lot with her face. Around 6 PM I was standing at the tip of her bed, smiling at her. Out of the clear blue sky she said, "Bobby, I'm thirsty". I might add in a strong voice. A couple of hours later I went once again to the tip of her bed and...Read Full Story

S-adenosyl methionine (SAM) contributes to multiple pathways in neuronal homeostasis, several of which are compromised in age-related neurodegeneration and Alzheimer's disease. Dietary supplementation of transgenic mice with SAM maintained acetylcholine levels, cognitive performance, oxidative buffering capacity, and phosphatase activity, and reduced aggression, calcium influx, endogenous PS-1 expression, γ-secretase activity, and levels of amyloid-β (Aβ) and phospho-tau. Herein, we examined...Read Full Story