Pancreatology 2009;9:240-244 (DOI: 10.1159/000212090) Background: Among the various studies of pancreatic function in the elderly published so far, none have dealt with subjects over 90 years of age. The aim of this study was to examine pancreatic function in healthy individuals over 90 years old. Methods: Sixty-eight healthy noninstitutionalized elderly persons, aged 91-104 years, with a mean age of 95 years, and 63 younger controls were studied. Pancreatic function was studied by determining fecal elastase 1 concentration. In addition to this test, we also measured serum amylase, pancreatic isoamylase and lipase in 53 of the 68 elderly subjects. Results: All but 1 of the ...
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Biochemistry (3rd Edition) (Biochemistry (Mathews/ Addison-Wesley)) Product Description: (Benjamin Cummings) Oregon State Univ., Corvallis. Introductory textbook for students taking a one-year biochemistry course. Includes new chapters. Previous edition: c1996. The CD-ROM contains an outline, concepts, terminology, and quizzing sections. System requirements: Windows 95/98/NT or MacOS 7.6.1+. List Price: USD 189.40 Lowest Used Price: USD 19.08 Lowest New Price: USD 25.35 Price is accurate as of the date/time indicated. Prices and product availability are subject to change. Any price displayed on the Amazon website at the time of purchase will govern the sale of this product. Average Rating: Author: Christopher K. Mathews Kensal E. van ...
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This book is intended for student and practitioners alike and is structured to bring the relevant disciplines together in one reference book. A key component of the quality of pharmaceutical drugs is the control of impurities. It is important to identify and quantify levels of impurities that may be present to provide safe, effective and well-controlled medicines. The measurement and identification of impurities to today’s standards presents significant challenges to the analytical chemist. The development of modern quantitative methods is driven by these challenges, and the rapid development of spectrometers has provided increasing opportunity to identify the structure, and therefore the origin and safety ...
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Department of Paediatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96826, United States. WMatsuno@Creighton.edu INTRODUCTION: Pancreatic injuries occur in up to 10% of paediatric patients who suffer blunt trauma. Initial amylase and lipase measurements have not been helpful as a screening tool to detect pancreatic injuries. However, one primarily adult study suggests that a delayed measurement may be useful. MATERIALS AND METHODS: A retrospective chart review was conducted of patients admitted to a Level I paediatric trauma centre from April 1996 to November 2006 with traumatic pancreatic injuries. RESULTS: The trauma database identified 51 patients with traumatic pancreatic injuries. Inclusion ...
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Abstract Background: Definitive substrates for the measurement of pancreatic lipase activity in human serum have not been conclusively identified owing to poor aqueous solubility and nonspecific susceptibility of substrates with existing methods. Thus, it is still important to propose new substrates for robust lipase measurements. Methods: Reaction conditions were studied for a lipase method using newly synthesized 2,3-dibutyrylthio-1-propyl oleate as the substrate and 5,5′-dithio-bis-(2-nitro-benzoic acid) as the chromogen. Results: Optimum conditions, using colipase and Mg++ in aqueous hexamethyl phosphoric triamide medium at pH 9.2, were defined. The substrate was highly selective to pancreatic lipase . The reaction increased linearly with lipase concentrations up to ...
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