Meyer's film debut was in the TV film Strapped in 1993, although her role in the cyberpunk thriller Johnny Mnemonic was perhaps her breakthrough performance. Before that, however, she also had a role in the TV series Beverly Hills 90210 as Lucinda Nicholson. In addition to Johnny Mnemonic, she has had other roles in science fiction productions, such as Starship Troopers, Birds of Prey and Star Trek Nemesis. Three of her most recent films were the 2004 horror/thriller hit Saw, followed by Saw II and its sequel Saw III. She made several guest appearances on Friends and Miss Match. She also played one of the leads on the now canceled Point Pleasant. In March 2006 Meyer was in the series premiere episode of Thief as Wanda, the wife of Andre Braugher's character, Nick. However, her character was killed in the first episode in a car wreck.
She reprised her role as Kerry in the third installment of the Saw series Saw III, released on October 27, 2006.
| Year | Title | Role | |
|---|---|---|---|
| 1990 | Beverly Hills, 90210 | Lucinda Nicholson | |
| 1995 | Johnny Mnemonic | Jane | |
| 1996 | Dragonheart | Kara | |
| 1997 | Starship Troopers | Dizzy Flores | |
| 1999 | Bats | Dr. Sheila Casper | |
| 2000 | Secret Agent Man | Holliday | |
| 2002 | Birds of Prey | Barbara Gordon, The Oracle/Batgirl | |
| Star Trek Nemesis | Romulan Commander Donatra | ||
| 2003 | The Movie Hero | Elizabeth Orlando / The Love Interest | |
| 2004 | Saw | Detective Allison Kerry | |
| 2005 | Point Pleasant | Amber Hargrove | |
| Wild Things: Diamonds in the Rough | Kirsten Richards | ||
| Saw II | Detective Allison Kerry | ||
| 2006 | Saw III | Detective Allison Kerry | |
| 2007 | Decoys 2: Alien Seduction | Dr. Alana Geisner | |
| Saw IV | Detective Allison Kerry | ||
| Crazy Eights | Jennifer Jones |