From api.bing.com
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A new study at Sydney's Victor Chang Cardiac Research Institute showed that traits can be changed through "epigenetic" changes, which could have implications for a number of trends and changes in our population, such as the obesity epidemic.
- Exploring the Role of Epigenetics (api.bing.com)
- Epigenetics: A Turning Point in Our Understanding of Heredity (rss.sciam.com)
- Genentech Backs Epigenetics (pharmtech.findpharma.com)
The chemical modification of histones at specific DNA regulatory elements is linked to the activation, inactivation and poising of genes. A number of tools exist to predict enhancers from chromatin modification maps, but their practical application is limited because they either (i) consider a smaller number of marks than those necessary to define the various enhancer classes or (ii) work with an excessive number of marks, which is...
From nar.oxfordjournals.org
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- Linking Expressed Genome to Environment: Epigenetics (thepoultrysite.com)
Background:
Variations in gene expression, mediated by epigenetic mechanisms, may cause broad phenotypic effects in animals. However, it has been debated to what extent expression variation and epigenetic modifications, such as patterns of DNA methylation, are transferred across generations, and therefore it is uncertain what role epigenetic variation may play in adaptation.
Results:
In Red Junglefowl, ancestor of domestic chickens, gene...
From biomedcentral.com
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- In Posidonia oceanica cadmium induces changes in DNA methylation and... (jxb.oxfordjournals.org)
Roche’s Genentech will pay Constellation Pharmaceuticals $95 million in up front fees and research funding as part of an epigenetics and chromatin biology collaboration focused on the discovery and development of new drugs for cancer and other ...
From api.bing.com
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- Genentech Pours $95 Million into Constellation Pharmaceuticals Epigenetic... (rss.biospace.com)
- Genentech commits $95M to Constellation Pharma cancer programs (bizjournals.com)
Rationale:
Epigenetic marks are crucial for organogenesis, but their role in heart development is poorly understood. Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, which establishes H3K27me3 repressive epigenetic marks that promote tissue-specific differentiation by silencing ectopic gene programs.
Objective:
We studied the function of PRC2 in murine heart development using a tissue-restricted conditional...
From circres.ahajournals.org
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- Fruitfly genome mapped in three dimensions (api.bing.com)
Astex Pharmaceuticals, Inc. (NASDAQ: ASTX) today announced that the multi-year collaboration to discover cancer therapeutics based on epigenetic targets entered into by SuperGen, Inc. and GlaxoSmithKline (GSK) in November 2009 is terminating and existing research work and assets generated under the CLIMBT epigenetic collaboration will be transferred to GSK.
From bioresearchonline.com
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- Astex Announces Early Transfer of Epigenetics Project to GSK (api.bing.com)
DNA methylation, a key component of the epigenome involved in regulating gene expression, is initially acquired in the germ line at millions of sites across the genome. Altered sperm methylation patterns are associated with infertility and transgenerational effects in humans and rodents. Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with...
From toxsci.oxfordjournals.org
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- Drug transporter regulation (biomedcentral.com)
SAN DIEGO, Feb 06, 2012 (BUSINESS WIRE) -- At the 1st annual Society for Laboratory Automation and Screening Conference in San Diego, PerkinElmer, Inc., a global leader focused on improving the health and safety of people and the environment, today ...
From api.bing.com
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- DNA Analysis Kit is designed for epigenetic research. (api.bing.com)
- DiscoveRx Corporation Continues to Innovate with Solutions for Epigenetic... (rss.biospace.com)
- Picking ChIP-seq peak detectors for analyzing chromatin modification... (nar.oxfordjournals.org)
Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer. Genome Res. doi:10.1101/gr.118919.110 4. Cutting-edge methods to detect the genes and networks that drive cancer The special Cancer ...
More perspectives...
From api.bing.com
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Limited forms of Lamarkian inheritance, such as in the operation of metabolism, seem to be a reality, passed down through generations by epigenetic modifications. Here is a popular science article on the topic: researchers "described a series of experiments that caused nematodes raised under the same environmental conditions to experience dramatically different lifespans. Some individuals were exceptionally long-lived, and their descendants...
More perspectives...
From longevitymeme.org
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Overview
Epigenetics means "above genetics". It deals with how the genes are switched on and off.
