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KEGG pathway analysis of the AIDS virus HIV1/host interactome

By chriscar22 on | From polygenicpathways.blogspot.com
Image via Wikipedia The NCBI database of HIV -1 virus/ host interactions database records almost 1500 interactions between HIV-1 and human proteins. When mapped out with KEGG pathways it is possible to see the myriad processes affected by the virus during its life cycle. These include many pathways relevant to the associated "side effects" of viral infection including dementia ( Alzheimer's pathway) , or psychosis ( ERBB signalling or LTP ). Numerous immune related pathways are also affected...Read Full Story

PLoS Biology: Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

By chriscar22 on | From polygenicpathways.blogspot.com
This study shows a very important link between infection and cholesterol metabolism  mediated by negative regulation of the complete sterol pathway by viral infection or treatment with interferon beta or interferon gamma Decreased sterol metabolism in turn exerted antiviral effects - However inhibition of viral growth was  not due to cholesterol deprivation, but to a pathway involving a proximal mevalonate-prenylation step. farnesyl diphosphate synthase knockdown also inhibited viral...Read Full Story

KEGG pathway analysis of the HIV-1/host interactome

By chriscar22 on | From polygenicpathways.blogspot.com
The HIV-1 AIDS virus interacts with a large number of host proteins which etch out a number of signalling networks. These are related to the viral life cycle and to pathogen defense and to many immune related pathways. Pathways related to comorbid conditions such as NeuroAids , dementia or psychosis are also well represented. Herpes simplex host/pathogen interactome pub-5799224524264318Read Full Story

KEGG pathway analysis of Autism susceptibility genes

By chriscar22 on | From polygenicpathways.blogspot.com
This analysis of several hundred Autism susceptibility gene candidates highlights MAPK , calcium, and neurotrophin pathways, among others,  as well as numerous adhesion related networks. As with many other diseases, immune networks are well represented , as are pathogen entry and defence pathways. Other KEGG pathway analyses of polygenic diseases pub-5799224524264318Read Full Story

Escort amsterdam Experience the Rich Culture of Amsterdam

By escortamsterpmm on
Full Service escort amsterdam Nieuwezijds Voorburgwal 21 1st floor, 1012 RC Amsterdam 020 626 7500 Amsterdam is instantly recognisable for its historic bridges over the picturesque 17th century winding canals which flow through the entire city, the narrow, cobbled streets, buzzing European caf culture and perhaps now notorious for its progressive nightlife. Situated in North Holland, this romantic city enjoys a rich history that has undergone some dramatic changes while still maintaining its...Read Full Story
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