Molecular Biology

Molecular Biology

A Molecular Biology guide, with links, news, and comments. Molecular biology is the study of biology at a molecular level. The field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry.

Harvard and MIT researchers have demonstrated a way to build more powerful artificial visual systems, taking inspiration from screening techniques in molecular biology (a multitude of candidate organisms or compounds are screened in parallel to find those that have a particular property of interest). "Reverse-engineering a biological visual system--a system with hundreds of millions of processing units--and building an artificial system that...  
From kurzweilai.net ()
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EMBL scientists are the first to visualize the mechanism responsible for oskar mRNA transportIn the fruit fly Drosophila, oskar mRNA, which is involved in defining the animal's body axes, is produced in the nuclei of nurse cells neighboring the oocyte, and must be transported to the oocyte and along its entire length before being translated into protein.Scientists in the group of Anne Ephrussi at the European Molecular Biology Laboratory (EMBL...  
From redorbit.com ()
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Taking inspiration from genetic screening techniques, researchers from Harvard and MIT have demonstrated a way to build better artificial visual systems with the help of low-cost, high-performance gaming hardware. The neural processing involved in  
From p.moreover.com ()
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A large proportion of late-stage breast cancers that have spread to other parts of the body (metastatic breast cancers) are characterized by overexpression of the protein Mdm2. Lindsey Mayo and colleagues, at Indiana University School of Medicine, Indianapolis, have now determined what drives this increased Mdm2 expression and found that Mdm2 helps promote cancer cells take on more aggressive characteristics, making it a potential target for...  
From medicalnewstoday.com ()
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IntroductionRenal insufficiency increases the half-life of low molecular weight heparins (LMWHs). Whether continuous venovenous hemofiltration (CVVH) removes LMWHs is unsettled. We studied hemostasis during nadroparin anticoagulation for CVVH, and explored the implication of the endogenous thrombin potential (ETP). Methods: This cross-over study, performed in a 20-bed teaching hospital ICU, randomized non-surgical patients with acute kidney...  
From biomedcentral.com ()
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Written by switbd on
What are the bare essentials of life, the indispensable ingredients required to produce a cell that can survive on its own? Can we describe the molecular anatomy of a cell, and understand how an entire organism functions as a system? These are just some of the questions that scientists in a partnership between the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Centre de Regulacio Genòmica (CRG) in Barcelona, Spain, set out to address. In three papers published back-to-back in Science, they provide the first comprehensive picture of a minimal cell, based on an extensive quantitative study of the biology of the ... Read Full Story
Written by invest_koe on
The European Molecular Biology Laboratory [EMBL] is an international research organisation with its main laboratory in Heidelberg [Germany], and four outstations in Hinxton, [UK] [the European Bioinformatics Institute, EBI], Grenoble [France], Hamburg [Germany], and Monterotondo [Italy]. Our research projects are interdisciplinary and offer exciting opportunities for biologists, chemists, physicists, mathematicians, informaticians, engineers and medical graduates who want to pursue a PhD in the molecular life sciences. Do you want to work in an international environment and in small groups with close contact to mentors? Collaboration and collegiality are hallmarks of the successful and fun EMBL culture. Whether you are looking for a friendly lab ... Read Full Story
Written by tims3429 on
Mycobacterium tuberculosis is the most common infecti ous agent in the world. Nearly 1/3 of the world population is infected , and a drastic numbe r of these are increasingly antibiotic resistant. MDR-TB and XDR-TB are becoming more commonplace everyday, especiall y in regions that are combating HIV infections. As such, it is incredibly important to study how this bu g works. It is one of the most difficult organisms to work with due to a wide variety of factors. These include: slow growth rate, pathogenicity, very waxy cell walls, high levels of illegitimate recombination, and a bunch of other nuances that make the ... Read Full Story
Written by tims3429 on
The most obvious use of phages is of course direct phage therapy. Although exciting, there are many other uses of phage that are just as revolutionary, but tend to slip by. In my last article, I hinted at a method in molecular biology called “recombineering.” (Short for homology-dependent, recombination-mediated, genetic engineering) This is a method whereby phage proteins are used to catalyze homologous recombination. The ramifications are huge. Mutations can be made; whole genes and operons can be knocked out with relative ease, and much more. In fact, some may say that this recently described process revolutionized E. coli genetics. Since this system was ... Read Full Story
Written by tims3429 on
Genetic recombination is a ubiquitous event that occurs in every species; it is necessary for the production of unique gametes, it is involved in DNA damage repair, it provides a mechanism for evolution, and it is a required action for many viruses and phages to undergo nucleic acid replication.(My discussion here will focus entirely on recombination in prokaryotes and their viruses) There are three different types of recombination: homologous recombination--where DNA of significant sequence similarity recombines, non-homologous recombination--where DNA without significant sequence similarity recombines (usually along gene boundaries), and finally there is illegitimate recombination--where DNA recombines randomly. Although DNA is surprisingly fluid, there are ... Read Full Story
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