From docuticker.com
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Indications
Plavix is indicated for:
* Prevention of vascular ischaemic events in patients with symptomatic atherosclerosis
* Acute coronary syndrome without ST-segment elevation, along with aspirin
It is also used, along with aspirin, for the prevention of thromboembolism after placement of intracoronary stent.
Most consensus-based therapeutic guidelines recommend the use of Plavix, over aspirin, in patients requiring antiplatelet therapy but with a history of gastric ulceration, as inhibition of the synthesis of prostaglandins by aspirin can exacerbate this condition. A recent study has shown that in patients with healed aspirin-induced ulcers, however, patients receiving aspirin plus the proton pump inhibitor esomeprazole had a lower incidence of recurrent ulcer bleeding than patients receiving clopidogrel.
Dosage forms
Plavix is marketed as clopidogrel bisulfate, most commonly under the trade name Plavix, as 75 mg oral tablets.
Adverse effects
Serious adverse drug reactions associated with Plavix therapy include:
* Severe neutropenia
* Thrombotic thrombocytopenic purpura
* Hemorrhage - The incidence of hemorrhage may be increased by the co-administration of aspirin.
* Erectile Dyfunction
Source:
http://en.wikipedia.org/wiki/Plavix
Plavix is indicated for:
* Prevention of vascular ischaemic events in patients with symptomatic atherosclerosis
* Acute coronary syndrome without ST-segment elevation, along with aspirin
It is also used, along with aspirin, for the prevention of thromboembolism after placement of intracoronary stent.
Most consensus-based therapeutic guidelines recommend the use of Plavix, over aspirin, in patients requiring antiplatelet therapy but with a history of gastric ulceration, as inhibition of the synthesis of prostaglandins by aspirin can exacerbate this condition. A recent study has shown that in patients with healed aspirin-induced ulcers, however, patients receiving aspirin plus the proton pump inhibitor esomeprazole had a lower incidence of recurrent ulcer bleeding than patients receiving clopidogrel.
Dosage forms
Plavix is marketed as clopidogrel bisulfate, most commonly under the trade name Plavix, as 75 mg oral tablets.
Adverse effects
Serious adverse drug reactions associated with Plavix therapy include:
* Severe neutropenia
* Thrombotic thrombocytopenic purpura
* Hemorrhage - The incidence of hemorrhage may be increased by the co-administration of aspirin.
* Erectile Dyfunction
Source:
http://en.wikipedia.org/wiki/Plavix
FDA Announces New Warning on Plavix: Avoid Use with Prilosec/Prilosec OTC
Source: U.S. Food and Drug Administration
Patients should avoid using the stomach acid reducer Prilosec/Prilosec OTC (omeprazole) with the anti-clotting drug Plavix (clopidogrel), the U.S. Food and Drug Administration warned on Nov. 17.
New data suggest that when patients take both Prilosec and Plavix, Plavix’s ability [...]
- FDA Announces New Warning On Plavix: Avoid Use With Prilosec/Prilosec OTC (medicalnewstoday.com)
Filed under: Bristol-Myers Squibb (BMY), Stocks to BuyBiopharmaceutical company Bristol-Myers Squibb (BMY) is performing on schedule, which is why I'm reiterating my buy rating for the company's shares, first recommended on June 1, 2009 at a price of $20.11. If you bought BMY in June, you're up about 24%.Look for a 6-8% revenue increase for BMY in 2010, boosted by revenue gains in key proprietary drugs, led by Plavix (for the prevention of...
From bloggingstocks.com
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- AstraZeneca Drug Outperforms Plavix in Heart Attack Study (dbtechno.com)
- clopidogrel-PPI interaction (amicor.blogspot.com)
- Financial Report: Bristol-Myers Squibb 3Q (feedburner.com)
An experimental anti-clotting drug being developed by AstraZeneca was shown to be more effective than Plavix® (clopidogrel) in treating heart patients who have the most serious type of acute coronary
read more
More perspectives...
From emaxhealth.com
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BOSTON (MarketWatch) -- The Food and Drug Administration warned Tuesday that taking the blood-thinner Plavix with the antacid Prilosec can reduce Plavix's effectiveness by as much as half. Plavix, the world's second best-selling drug, is co-marketed by Sanofi-Aventis and Bristol-Myers Squibb . Prilosec, also known as omeprazole, belongs to a group of widely-used antacids called PPIs. The agency also advised against taking Plavix with the...
From marketwatch.com
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- FDA warns heartburn drugs interfere with Plavix (reuters.com)
The pharmaceutical landscape is rapidly changing as patents for some of the blockbuster drugs of the last decade near expiration and other players try to grab some of the remaining revenues before generic medications flood the market. AstraZeneca (AZN) announced Thursday morning that it has filed a New Drug Application with the FDA for its antiplatelet treatment ticagrelor. The drug is meant to treat major cardiac events in patients with acute...
From minyanville.com
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- Stint (cr4.globalspec.com)
A new Public Health Advisory from the FDA was published on November 17th. The FDA has new data showing a drug interaction between the drug omeprazole (Prilosec and Prilosec OTC) and clopidogrel (Plavix) which reduces the effects of the clopidogrel...
From findlaw.com
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- Drugs can interfere with Plavix (spokesmanreview.com)
- Plavix Users Warned Not to Take Prilosec, Nexium (personalinjurylawnews.com)
- FDA says Prilosec can block benefits of Plavix (rss.msnbc.msn.com)
Avoid dangerous combination: Blood thinner Plavix with some heartburn drugs
The Food and Drug Administration warned today that people who take the blood thinner clopidogrel (Plavix) should not take the heartburn drugs omeprazole (Prilosec, Prilosec OTC, and generics) and esomeprazole (Nexium) because two new studies confirm that the combination could have dangerous consequences. The...
From simplefeed.consumerreports.org
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- FDA says heartburn drugs can interfere with Plavix (mynorthwest.com)
- Certain Heartburn Drugs Interfeer with Plavix Blood Thinner (dbtechno.com)
- Correction: Plavix story (rss.news.yahoo.com)
