Indications
Plavix is indicated for:
* Prevention of vascular ischaemic events in patients with symptomatic atherosclerosis
* Acute coronary syndrome without ST-segment elevation, along with aspirin
It is also used, along with aspirin, for the prevention of thromboembolism after placement of intracoronary stent.
Most consensus-based therapeutic guidelines recommend the use of Plavix, over aspirin, in patients requiring antiplatelet therapy but with a history of gastric ulceration, as inhibition of the synthesis of prostaglandins by aspirin can exacerbate this condition. A recent study has shown that in patients with healed aspirin-induced ulcers, however, patients receiving aspirin plus the proton pump inhibitor esomeprazole had a lower incidence of recurrent ulcer bleeding than patients receiving clopidogrel.
Dosage forms
Plavix is marketed as clopidogrel bisulfate, most commonly under the trade name Plavix, as 75 mg oral tablets.
Adverse effects
Serious adverse drug reactions associated with Plavix therapy include:
* Severe neutropenia
* Thrombotic thrombocytopenic purpura
* Hemorrhage - The incidence of hemorrhage may be increased by the co-administration of aspirin.
* Erectile Dyfunction
Source:
http://en.wikipedia.org/wiki/Plavix