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Editor's Note: Main Cast Members
(source Wikipedia):

  • Dominic Purcell as Lincoln Burrows (Season 1– ): Lincoln is a high school dropout and a convicted felon, who is wrongfully accused of and charged with the murder of Terence Steadman, the brother of the Vice President of the United States. Purcell was cast three days before the start of production and consequently, he was the last actor to join the original cast.[20] He auditioned for the role while he had a recurring role as Tommy Ravetto on North Shore. Since working on John Doe, Purcell has had an amiable relationship with Fox. Hence, he was sent the pilot script of Prison Break.[3] At first, Scheuring thought Purcell was "too much of a pretty boy" after he went to the audition with his hair styled and a tan. However, Purcell won the role and arrived on the set on the first day of filming with a shaved head, which amazed Scheuring with the physical likeness of the series' two leading actors.[21]
  • Wentworth Miller as Michael Scofield (Season 1– ): Michael is Lincoln's brother and worked as a structural engineer before devoting full-time to his brother's case. In order to save his brother's life, Michael creates an elaborate plan to help his brother escape from prison. In an interview, Paul Scheuring recalled that most of the actors who tested for the role "would come in playing mysterious, but it was so cheesy and false."[21] A week before the start of production, Miller auditioned for the role and impressed Scheuring with his performance; he was cast the following day.[20]
  • Robin Tunney as Veronica Donovan (Season 1): Veronica is Michael and Lincoln's childhood friend and decides to review Lincoln's case at Michael's insistence. She becomes Lincoln's lawyer and appears as a major character in the first season.
  • Marshall Allman as L. J. Burrows (Season 1–): L. J. is the teenage son of Lincoln Burrows and is greatly affected by his father's death sentence. He is forced into hiding after he becomes the target of the people who want Lincoln dead.
  • Amaury Nolasco as Fernando Sucre (Season 1– ): Sucre develops a friendship with Michael during time at Fox River State Penitentiary, where he was his cell-mate. He becomes Michael and Lincoln's ally, and provides comic relief to the show. His character's story focuses mainly on his wish to reunite with his girlfriend. Upon receiving the pilot script, Nolasco's first thought was that it was "one of those failed pilots that the network didn't really want" since most of the series pilots would have started production by that time. Admitting that he doesn't like to read, Nolasco was amazed that the script was a "huge page-turner". Prior to his last audition for the role, Nolasco recalled his nervousness, which grew when Paul Scheuring told him that he was their favourite choice. Subsequently, he was cast in the role.[22]
  • Robert Knepper as Theodore "T-Bag" Bagwell (Season 1– ): T-Bag appears in all four seasons of the series as a cunning, violent and manipulative psychopath, consistently underestimated by those around him.
  • Peter Stormare as John Abruzzi (Season 1-2): Due to his role as the leader of a Chicago mafia, Abruzzi became a prominent figure at Fox River State Penitentiary. He agrees to provide an escape plane for Michael in exchange for the location of the eyewitness to his crimes, Otto Fibonacci. He appears regularly in the first half of the first season and makes selected appearances towards the end of the first season and the beginning of the second season.
  • Rockmond Dunbar as Benjamin Miles "C-Note" Franklin (Season 1–2): Desperate for his family, C-Note blackmails Michael at Fox River to join his escape team. He appears in the series as a major character in the first and second seasons.
  • Wade Williams as Brad Bellick (Season 1–4): Appearing in all four seasons, Bellick was introduced as the captain of Fox River's correctional officers. After reading the pilot script, Williams initially did not want to portray the role of Bellick because the character was "horrible and despicable". His reluctance stemmed from being the father of a four-year-old daughter. However, his manager persuaded him to audition for the role and Williams landed the role of Bellick.[22]
  • Sarah Wayne Callies as Sara Tancredi (Season 1–2, 4– ): Sara is the prison doctor at Fox River and the daughter of Governor Frank Tancredi, who is linked into the plot that brings Lincoln to Fox River. She takes a liking to Michael and eventually becomes his love interest; she aids his escape and ultimately joins them on the run. Callies was the first actress the producers saw at the audition for the role of Sara Tancredi[20] and was also the first to become a principal cast member.[23]
  • Paul Adelstein as Paul Kellerman (Season 1–2): Kellerman was introduced as a Secret Service agent working for the Vice President to make sure that the execution of Lincoln Burrows goes smoothly. Eventually, his character changes from that of a villain to an ally to Michael and Lincoln. He appears as a major character in the first and second seasons.
  • William Fichtner as Alexander Mahone (Season 2– ): Introduced as an FBI agent in the second season, Mahone's assignment was to locate the fugitives. Mahone is intellectually matched with Michael and his background unfolds as the series progresses. In season 3 he finds himself incarcerated with Michael in Sona and is eventually forced to become his ally through season 4.
  • Robert Wisdom as Lechero (Season 3): Appearing as a major character in the third season, Lechero is a prisoner at Sona and a Panamanian drug kingpin.
  • Chris Vance as James Whistler (Season 3): Whistler is incarcerated in Sona for the murder of the Mayor's son and appears as a major character in the third season.
  • Jodi Lyn O'Keefe as Gretchen Morgan (Season 3– ): Introduced as "Susan B. Anthony", Gretchen is an operative for the company who is in charge of ensuring the escape of James Whistler.
  • Danay Garcia as Sofia Lugo (Season 3– ): Sofia was introduced in the third season as Whistler's girlfriend.
  • Michael Rapaport as Don Self (Season 4– ): Introduced in season 4, Self is a Department of Homeland Security special agent who teams up with the protagonists to take down the company.

BELGRADE, Serbia -- Authorities say five prison guards have been detained on suspicion of helping two dangerous inmates, including one who was involved in the assassination of the prime minister, organize an attempted escape that was thwarted by police.  
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Wow, was I surprised when my computer actually did what I asked it to do. Nearly three years ago I told it to watch for and record an episode of Prison Break I had missed. Sure enough, Thursday the May 2009 episode came up on HDNET and the computer recorded it. After watching it I remembered how much I liked it and told the computer to record 'any' episode. This afternoon HDNET again showed an episode but it was one in the beginning of the...  
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Before entering the imposing Fox River prison facility, Michael Scofield - played by the impossibly handsome Wentworth Miller - has the finer details of his escape plan tattooed onto his body. Handily, Scofield helped to design Fox River himself and each ...  
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Until a massive change in California's prisons three months ago, these were the odds that Nate Bracy would be locked up again within three years: For having being released in California: 57 percent. For his latest offense having been possession ...  
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Sky NewsFace Of Gunman Who Aided Prison BreakSky NewsPolice have released an e-fit of the man accused of helping a dangerous criminal escape prison custody. The man is accused of aiding Category C inmate Andrew Farndon in a planned escape as he arrived by taxi at West Suffolk Hospital in Bury St Edmunds ...Andrew Farndon prison escape: E-fit of gunman releasedBBC NewsPolice release e-fit after prisoner escapesNewmarket JournalFace of man who...  
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A PROLIFIC car thief serving eight-and-a-half years in jail for a raid in which a farmer’s wife died spent three months on the run after absconding from an open prison, it emerged yesterday. Tony Aaron Blair vowed to “live a lawful and productive ...  
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Daily MailTracy Province: Convict who carjacked and killed couple during a prison break ...Daily MailTracy Province, 44, and Casslyn Welch, 45, who has acknowledged her role in the prison break, faced murder charges and could have faced the death penalty in the 2010 slayings of Gary and Linda Haas. Province and Welch agreed to plead guilty to charges ...and more »  
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Capital New York'A Man Escaped,' Bresson's pensive, otherworldly take on a prison breakCapital New YorkHow many prison-break films can say that? Not only did the story resonate with Bresson—himself a former POW—but it also allowed for an intersection of spirituality and realism, two of Bresson's primary concerns as a director. Fontaine has to decide ...and more »  
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Mainichi Daily NewsJustice minister eyes tougher penalty for prison breakMainichi Daily NewsHIROSHIMA (Kyodo) -- Justice Minister Toshio Ogawa indicated Wednesday the government will consider toughening a penalty for those who escape from prison in light of the escape of an inmate from a prison in Hiroshima Prefecture last week. ...and more »  
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