1. Cristina & Meredith - 'Grey's Anatomy'
Prickly Cristina Yang (Sandra Oh) and "dark and twisty" Meredith Grey (Ellen Pompeo) seemed like unlikely pals when Grey's Anatomy first hit the airwaves, but over the years the two surgeons have formed the show's greatest friendship. They are each other's "person" through thick and thin, hookups and breakups, and all other major hospital crises (including bombs and a rogue shooter).