From toxsci.oxfordjournals.org
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Multiple sclerosis (MS) is an autoimmune disease characterized by peripheral activation of CD4+ T cells that migrate into the central nervous system (CNS) and mount an autoimmune neuroinflammatory attack on myelin and oligodendrocytes. Secondary to these events, however equally destructive, is the generation of inflammatory-mediated reactive oxygen and nitrogen species secreted by persistently activated microglia and astrocytes. Nuclear factor...
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