Biochemistry - Articles - Zimbio

Lehninger Principles of Biochemistry, Fourth Edition

Thu, 12 Oct 2007 16:09:00 GMT

posted by genome

Just Uploaded lehninger 4rth edition from torrent!

This is one of my favourite biochemistry textbooks! If you want the hard cover, you can always get it at bookstores or amazon. I love free ebooks :-) ... so will be uploading some more later!

Please feel free to download it @
Lehninger Biochemistry 4e (2005).pdf
or Alternate Download Site

[Right click on the link and save as target to your destination folder]

Additional Information
http://bcs.whfreeman.com/lehninger/default.asp?s=&n;=&i;=&v;=&o;=&ns;=0&uid;=0&rau;=0

http://www.amazon.com/Lehninger-Principles-Biochemistry-Fourth-Nelson/dp/0716743396

Welcome to our blog about Biochemistry

Thu, 30 Jun 2006 23:59:54 GMT

posted by The_Zimbio_Team
This is our group blog, which is unique because any Zimbio member can post an entry to it. Some members blog about recent news and trends related to the portal topic, others recount relevant personal stories. You can also comment on and rate existing blog entries, to voice your opinion and to help the community identify which members and entries on the portal are must-reads. Got an interesting idea or story to share with other members of this portal? Well, then put on your journalist's cap and add your own blog entry!

Study: Reactions to Genetic Testing

Tue, 16 May 2007 17:45:55 GMT

posted by corrinekidd
As public access to health-related DNA genetic testing is increasingly marketed largely without government regulation, there are concerns about how the knowledge received from the test results will be used by the consumer and/or health care providers. Two agencies in the National Institutes of Health—the National Human Genome Research Institute and the National Cancer Institute—have teamed [...]

Ames Assay

Sun, 1 Oct 2007 09:31:00 GMT

posted by genome

Ames test, developed by Bruce Ames, is a widely used rapid and less-expensive screening test for potential mutagens.

Figure 1. The Ames test for mutagenicity. The test uses a strain of Salmonella bacteria that require histidine in the medium because of a defect in a gene necessary for histidine synthesis. Mutagens can cause a further change in this gene that reverses the defect, creating revertant bacteria that do not require histidine. To increase the sensitivity of the test, the bacteria also have a defect in their DNA repair machinery that makes them especially susceptible to agents that damage DNA. A key feature of this detection system is the inclusion of a mammalian liver homogenate as some potential carcinogens are converted into their active forms by enzyme systems in the liver or other mammalian tissues and bacteria lack these enzymes, and so the test plate requires a few milligrams of a liver homogenate to activate this group of mutagens. (Figure and text from Molecular biology of the Cell, IV Ed.)

Additional Information:

>Bruce N. Ames, E. G. Gurney, James A. Miller, and H. Bartsch (1973). "Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-acetylaminofluorene and other Aromatic Amine Carcinogens". PNAS 69: 3128-2132. PDF
>Bruce N. Ames, Frank D. Lee, and William E. Durston (1973). "An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens". PNAS 70: 782-6. PDF
>Joyce McCann, Neil E. Spingarn, Joan Kobori, and Bruce N. Ames (1975). "Detection of Carcinogens as Mutagens: Bacterial Tester Strains with R Factor Plasmids". PNAS 72: 979-83. PDF
>Bruce N. Ames, William E. Durston, Edith Yamasaki, and Frank D. Lee (1973). "Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection". PNAS 70: 2281-5. PDF