Régine Chassagne (born August 18, 1977) is a Canadian multi-instrumentalist musician and singer, and a founding member of the band Arcade Fire.
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- Birth name: Régine Alexandra Chassagne
- Born: ( 1976-08-19) 19 August 1976 (age 44) Montreal, Quebec, Canada
- Genres: Indie rock, art rock, dance-rock, baroque pop
- Instruments: Vocals, piano, keyboards/keytar, accordion, percussion, hurdy-gurdy, recorder
- Years active: 2000–present
- Associated acts: Arcade Fire, Les Jongleurs de la Mandragore