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Steamy 'Grey's Anatomy' Moments That Will Make You Hyperventilate

3. Izzie asked Alex to take off his pants.

Although Izzie and Alex didn't exactly have a fairytale romance, they certainly shared some out-of-this-world chemistry. When the Season 2 bomb scare left all the doctors on edge, Izzie revealed how long it had been since she last had sex. She probably didn't have to talk that much since Alex was into her big time from the very beginning.