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Robert Neville and Samantha
I Am Legend (2007)

The "last man on Earth," Robert Neville's (Will Smith) lone companion is his German Shepherd, Sam. Facing post-apocalyptic nothingness nothingness forever, he and Sam scour the city for any hope of a cure for the virus that wiped out everyone except for a small percentage who turned into hyper-aggressive vampire creatures. Robert is really tested when Sam is infected near the end.