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The Most Heartbreaking Star-Crossed Lovers In TV History

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19. Cristina Yang & Preston Burke, 'Grey's Anatomy'
Talk about a devastating breakup! After realizing that he was turning Cristina into the woman he wanted her to be rather than allowing Cristina to be who she was, Burke left her on their wedding day. He also packed up and moved out of their house without informing her and quit his job. Derek was the one who informed Cristina that Burke no longer worked at Seattle Grace. Here's the thing: If Isaiah Washington didn't stir up all that drama on the set of Grey's Anatomy, these two would have probably been endgame, given their personalities and unyielding brilliance.