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The Most Heartbreaking Star-Crossed Lovers In TV History

8. Lexie Grey & Mark Sloan, 'Grey's Anatomy'
The plane crash from hell came in like a wrecking ball and took out some of the best characters on Grey's Anatomy. Will anyone ever get their freakin' happily ever after on this show? When will the madness end, Shonda Rhimes? When will it end?