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1. Leighton Meester
As the beautiful and feared Queen Bee, Blair Waldorf later proved to be a much more complicated and vulnerable character. After Gossip Girl ended in 2012, Leighton Meester focused on independent films like Life Partners, The Judge, and Like Sunday, Like Rain. She also had a brief and unsuccessful music career. In 2014, Meester made her Broadway debut in John Steinbeck's Of Mice and Men, alongside James Franco and Chris O'Dowd.