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Extensively drug-resistant tuberculosis (XDR-TB) is defined as tuberculosis that is resistant to rifampicin and isoniazid (resistance to these first line anti-TB drugs defines Multi-drug-resistant tuberculosis), as well as to any member of the quinolone family and at least one of the following second-line TB treatments: kanamycin, capreomycin, or amikacin.
The old case definition of XDR-TB is MDR-TB that is also resistant to three or more of the six classes of second-line drugs. This definition should no longer be used.
The principles of treatment for MDR-TB and for XDR-TB are the same. The main difference is that XDR-TB is associated with a much higher mortality rate than MDR-TB, because of a reduced number of effective treatment options.
The epidemiology of XDR-TB is currently not well studied, but it is believed that XDR-TB does not transmit easily in healthy populations, yet is capable of causing epidemics in populations which are already stricken by HIV and therefore more susceptible to TB infection.
Source:
http://en.wikipedia.org/wiki/XDR-TB
The old case definition of XDR-TB is MDR-TB that is also resistant to three or more of the six classes of second-line drugs. This definition should no longer be used.
The principles of treatment for MDR-TB and for XDR-TB are the same. The main difference is that XDR-TB is associated with a much higher mortality rate than MDR-TB, because of a reduced number of effective treatment options.
The epidemiology of XDR-TB is currently not well studied, but it is believed that XDR-TB does not transmit easily in healthy populations, yet is capable of causing epidemics in populations which are already stricken by HIV and therefore more susceptible to TB infection.
Source:
http://en.wikipedia.org/wiki/XDR-TB
The number of people treated for MDR-TB reached 46,000 in 2010, but that represented only 16 per cent of the total estimated number of patients who needed treatment, the report said. Drug-resistant TB is caused by bacteria that do not respond to the ...
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more concerned about the extremely drug resistant tuberculosis (XDR-TB). Both of these are manmade problems, the result of inadequate care and treatment of standard tuberculosis. In the first reported outbreak of XDR-TB in KwaZulu-Natal Province ...
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SEATTLE -- The Bill & Melinda Gates Foundation today announced $7.7 million in funding for 10 new grants to identify biomarkers for diagnosing tuberculosis (TB) in low-resource settings. This new grant program, Biomarkers for the Diagnosis of Tuberculosis ...
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The World Health Organization (WHO) has ongoing programs to improve and monitor tuberculosis (TB). The WHO's 2011 report on global TB control provides the most comprehensive information ever collected on the problems and issues of disease, as well as deaths caused by TB and multidrug-resistant TB (i.e. disease marked by in vitro resistance to at least isoniazid and rifampicin). They also look at treatment outcomes, financing mechanisms and new...
From medicalnewstoday.com
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- Multidrug-Resistant Tuberculosis - Update (api.bing.com)
- Multidrug-Resistant TB Cases Increasing Worldwide (api.bing.com)
LONDON (AP) - The World Health Organization says the highest levels ever of drug-resistant tuberculosis have been found in Russia and Moldova.
But the agency didnt have data from most of Africa and India, where tuberculosis rates are much higher.
From mynorthwest.com
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- WHO finds very high levels of drug-resistant TB in Russia, Moldova (news-medical.net)
- Totally drug-resistant tuberculosis reported in Mumbai (api.bing.com)
... drop from 269 people among 100,000 people in 2002. "Cambodia has seen a great success in fighting against TB in the last decade; however, the country is still one of the highest TB burden in the region and the world," Mao Tan Eang, director of ...
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A few weeks ago a clinic in Mumbai claimed to have identified a dozen patients with a strain of tuberculosis (TB) resistant to all known treatments. TB is a highly contagious lung infection that kills about 1.5 million people each year worldwide ...
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Overview
XDR-TB is the drug resistant form of tuberculosis.
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