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We may like to think that the chemistry we see between two actors onscreen translates into real-life friendships, but that's not always the case.

Johnny Depp and Angelina Jolie didn't even pretend to be friendly at The Tourist premiere, Gossip Girl co-stars Blake Lively and Leighton Meester admitted they're not the best of friends, and it's no big secret that Sarah Jessica Parker and Kim Cattrall were TV's biggest frenemies for years.

Read on to see which other movie and TV co-stars weren't exactly BFFs.
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